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Oxidative Stress and Metabolism Research

Director: Hans-Joachim Lehmler, PhD

Co-Director: Jonathan A. Doorn, PhD

Research in oxidative stress and metabolism is central to the EHSRC because many rural environmental agents cause disease or pathological conditions by producing oxidative stress in cells. Oxidative stress is a condition where the rate of generation of oxidants exceeds the capacity of antioxidant enzymes to eliminate them. A large number of human diseases have oxidative stress as part of their mechanism. Agents leading directly to the increased production of free radicals and oxidants, as well as compromising antioxidant systems, include pesticides and a variety of chemicals and background radiation found in the rural environment. Moreover, metabolism of rural environmental agents by a range of metabolizing enzymes influences individual susceptibility to environmental exposures. Therefore, OSM is a critical element in environmental health research, embodying basic mechanistic approaches to the understanding and quantitation of health risks associated with environmental exposures. Importantly, understanding the interconnection between oxidative stress and metabolism will guide efforts aimed at developing intervention strategies, such as dietary interventions or clinical use of antioxidants, to reduce the burden of disease in at-risk populations.

This thematic area brings together Center researchers in the oxidative stress and xenobiotic metabolism fields as they relate to environmental lung disease and agricultural chemical-associated diseases, such as carcinogenesis, neurodevelopmental and neurodegenerative disorders.


Wei Bao, PhD

Garry R. Buettner, PhD
Free Radical & Radiation Biology

Andrean Burnett, PhD

Jonathan Doorn, PhD
Medicinal and Natural Products Chemistry

Michael W. Duffel, PhD

Anne E. Kwitek, PhD


Hans-Joachim Lehmler, PhD
Occupational Environmental Health

Gabriele Ludewig, PhD
Occupational Environmental Health

David W. Murhammer, PhD
Chemical and Biochemical Engineering

Andrew A. Pieper, MD, PhD

Larry W. Robertson, PhD
Occupational and Environmental Health

Douglas R. Spitz, PhD
Radiation Oncology